Innovation Series: Advanced Science (ISSN 2938-9933, CNKI Indexed)

Analysis of Breast Cancer Burden Trends in China (1990–2021) Using the GBD Database

Liting Yang^1,*, Ting Wei^1, Yao He²

¹ Nanchong Central Hospital/The second Clinical Medical College of North Sichuan Medical College, Nanchong, China

² Shuangqiao Town Health Center, Nanchong, China

Corresponding Author: Liting Yang

Abstract: Objective: To gain a comprehensive understanding of the long-term evolutionary patterns and gender disparities in breast cancer burden in China from 1990 to 2021, and to explore the association between the Age-Standardized Incidence Rate (ASIR) and the Socio-Demographic Index (SDI), so as to provide a scientific basis for formulating targeted prevention and control strategies.
Methods: Based on the 2021 Global Burden of Disease (GBD) dataset, four core indicators of breast cancer were extracted: number of deaths, Disability-Adjusted Life Years (DALYs), prevalence cases, and incidence cases. Descriptive statistics were used to analyze the distribution characteristics of indicators stratified by gender. The Joinpoint regression model was applied to calculate the Average Annual Percent Change (AAPC) and analyze the temporal trend of indicators. Pearson correlation analysis was conducted to examine the correlation between ASIR and SDI.
Results: From 1990 to 2021, the overall burden of breast cancer in China showed a significant upward trend, with the largest increase in prevalence (366.40%), followed by incidence (364.50%). The growth rate and annual average growth rate of all disease burden indicators in males were higher than those in females, while females accounted for the vast majority of the absolute disease burden. The age-standardized rates showed a fluctuating upward trend. Projections indicated that the female ASIR would continue to rise from 2021 to 2040 and remain much higher than that of males. There were significant regional differences in the incidence and prevalence of breast cancer worldwide, with obvious geographical clustering characteristics. ASIR was significantly positively correlated with SDI (r = 0.767, P < 0.001).
Conclusion: The burden of breast cancer in China continues to increase, posing an increasingly severe challenge to the healthcare system. Among them, the male disease burden grows rapidly and requires targeted attention. The levels of disease prevention and control vary significantly across regions. There is an urgent need to develop differentiated prevention and control strategies combining gender characteristics and regional epidemiological features to address this increasingly prominent public health issue.

Keywords: Breast cancer; Disease burden; Gender difference; Socio-Demographic Index; Age-standardized incidence rate 
 

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